Project titleAssessing the Role of αVβ6 Integrin Expression in Subpopulation of PC3 Cells

Integrins are heterodimeric transmembrane proteins that consist of an α and a β subunit that function as receptors for extracellular matrix proteins (ECM) and allow for the cells to participate in cell-cell and cell-matrix interactions. The integrin, αVꞵ6, is known to activate transforming growth factor-β (TGF-β) where elevated levels of αVꞵ6 has been linked to poor prognosis in cancer (John et al., 2020). In addition, αVꞵ6 is known to mediate cell adhesion and migration through binding to ECM molecules such as fibronectin, tenascin-C and vitronectin (Koivisto, Häkkinen, & Larjava, 2018). Our research has determined a subpopulation of PC3 prostate cancer cells that express αVꞵ6. This subpopulation is not found in DU145 prostate cancer cells. Our findings determined that this subpopulation is not caused by the media the cells are cultured in. 

Primary contact nameLaila Assami
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Students/participant(s) programs
  • Biological Sciences
Faculty advisor(s)
Advisor name Email Affiliation
Mohamed Bouaouina CMUQ
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  • Biological Sciences